29Aug

Senior Scientist, CMC Digital Product Development at Takeda – USA – MA – Cambridge


By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Join Takeda as a Senior Scientist, CMC Digital Product Development, CMC Digital Product Development where you will be tasked with designing and iterating a data ecosystem to provide scientists and business leaders with the right data, and to help ask the right questions, at the right time. You will be working alongside lab SME, Data Engineering, and the Emerging Technologies team to help digitize our process development, analytical development, and manufacturing workflows and enable cross-functional access to data.

You will be working with the Cell Therapy Process Development team and will be a qualified DD&T leader to drive CMC digitalization technologies and endpoints across Takeda pipeline and platform activities. You will report to Head, Digital Solutions & Applied Informatics.

How you will contribute:

  • Apply advanced techniques to complex data science challenges in R&D and other organizations.

  • Work directly with Data Science teams in R&D at Takeda along with other advanced analytics organizations across the company.

  • Work directly with lab Scientists to understand and develop solutions for capturing, handling, and reporting of experimental data

  • Apply advanced techniques in structured, partly structured, and unstructured data across different partner organizations. 

  • Implement solutions for difficult-to-structure data sets.

  • Maintain up-to-date knowledge of modern data technologies and explore new platforms and beta tooling.

  • Independently use your judgment to identify data requirements and iterate and expand the ecosystem design.

  • Influence new computer science platforms to design, analyze, and implement complex and new data-driven solutions that impact the company.

  • Provide leadership to complex data analysis, use and explore data, languages, tools, and software to best construct data for predictive modeling, test the model, and train data to deploy the modeling within a complex R&D, Medical, Mathematical environment and a large complexity of IT systems and data.

  • Interface and manage technical development team to development fit for purpose digital solutions.

Minimum Requirements/Qualifications:

  • Bachelor’s degree or higher in computer science or similar/applicable field or equivalent experience.

  • 6+ years experience as a software engineer OR 2+ years experience as a tech lead/engineering manager on a team delivering frontend code.

  • Expertise with one or more modern Javascript frameworks (React, Vue, AngularJS).

  • Experience with Node.js.

  • Experience leading projects and managing requirements with non-technical stakeholders.

  • Experience with data visualization.

  • Benefit to have experience with concepts of Graph Data and metadata storage (AWS Nep-tune, Apache Jena Fuseki)

  • Benefit to have experience with: Clojure, ClojureScript, Python.

  • Benefit to have direct experience working in Cell Therapy and/or Mammalian Biology labs.

  • Benefit to have experience working in Process Development or Manufacturing environments

  • Benefit to have experience working with the AWS ecosystem.

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices. 

For Location:

Boston, MA

U.S. Base Salary Range:

$133,000.00 – $209,000.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location. 

U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation. 

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time



Source link

29Aug

Seeding GPT-4o-mini Using Fine-Tuning | by Cobus Greyling | Aug, 2024


There are several reasons why one might choose to use this approach:

Simplified Reproducibility: Fine-tuning a model with input/output pairs for reproducibility allows you to offload much of the complexity and software infrastructure to OpenAI.

This means that the data, along with the seed reference, is embedded within the model itself, streamlining administration and ensuring availability.

Precision in Use Cases: By using seeding, you can precisely target different fine-tuned datasets for various user scenarios.

This enables more tailored and consistent responses depending on the specific context in which the model is being used.

Fine-tuning can also be versioned, and if a newer version of the data is used for fine-tuning, this can be tracked via fine-tuning.

Inference Segmentation: Inference can be segmented into two categories: general information and specific information on which the model is fine-tuned.

This allows the model to distinguish between providing broad, generalised responses and delivering more precise answers based on the specialised training it has received.

Considerations

Fine-tuned models that have already been created from these base models will not be affected by this deprecation.

However, you will no longer be able to create new fine-tuned versions using these models.

Although this approach is appealing due to its simplicity and no-code nature, it does create model dependency, making it difficult to migrate to another model or AI provider.

The advantage of a RAG (Retrieval-Augmented Generation) framework is that it offers a degree of model independence, allowing AI models to be treated more like interchangeable utilities.

This flexibility can simplify transitions between different models or providers, reducing the risk of being locked into a single ecosystem.

Large Language Models primarily rely on unstructured natural language input and generate output through Natural Language Generation (NLG).

A key aspect of fine-tuning, as with RAG, is to provide the Language Model with contextual reference during inference.

This process is known as In-Context Learning (ICL). ICL enables the Language Model to temporarily set aside its base knowledge and instead leverage the specific contextual data supplied, allowing for more accurate and relevant responses based on the given context.

Below is Python code you can copy as-is and paste into a notebook. You can see the question is asked, What is X? and without the necessary context, this question is very ambiguous.

pip install -q openai
#####
import os
#####
os.environ['OPENAI_API_KEY'] = str("")

#####
from openai import OpenAI
client = OpenAI()

response = client.chat.completions.create(
model="gpt-4o-mini-2024-07-18",
messages=[
{
"role": "system",
"content": "You should help to user to answer on his question."
},
{
"role": "user",
"content": "What is X?"
}
],
temperature=1,
max_tokens=150,
top_p=1,
frequency_penalty=0,
presence_penalty=0,
seed=1
)
print(response)

Therefore, considering the output from the gpt-4o-mini-2024–07–18 model, the model is attempting to disambiguate the input by casting the question into different contexts.

This process involves analysing the question to identify multiple potential interpretations, allowing the model to respond more accurately based on the inferred context.

ChatCompletion(id='chatcmpl-A1UX0BcHnsoy7EPnRUqJHp4F0CToW', 
choices=[Choice(finish_reason='length',
index=0, logprobs=None,
message=ChatCompletionMessage(content='The question "What is X?"
is quite broad and can refer to many things depending on the context.
Here are a few possibilities:\n\n1.

**Mathematics**: In an equation, X often represents an unknown variable
that needs to be solved.\n2.

**Algebra**: X can be a placeholder for any
number in algebraic expressions.\n3.

**Science**: X could refer to a
variable in experiments or a certain element in chemistry (like X-rays).\n4.
**Popular culture**: X could refer to a character, a title, or a brand name
(like "X-Men" or "X-Factor").\n5.

**Programming**: In computer science, X might stand for a parameter or a
specific data type', refusal=None, role='assistant',

function_call=None, tool_calls=None))],
created=1724919054,
model='gpt-4o-mini-2024-07-18',
object='chat.completion',
service_tier=None,
system_fingerprint='fp_5bd87c427a',
usage=CompletionUsage(completion_tokens=150, prompt_tokens=26, total_tokens=176))

However, below is a snippet from the training data where the context of X is defined…



Source link

29Aug

Head of Business Performance

Job title: Head of Business Performance

Company: eBay

Job description: Analysts and will report into the Senior Director of Strategy, Innovation and Business Performance. This team is accountable… and shaping Strategy and innovation. Owning the business performance team of two direct reports encouraging collaboration…

Expected salary:

Location: Dublin

Job date: Wed, 21 Aug 2024 03:14:18 GMT

Apply for the job now!

29Aug

Business Development Associate Director

Job title: Business Development Associate Director

Company: Ardmac

Job description: Job purpose The Life Sciences Business Development Associate Director will play a pivotal role in driving growth… within the company. They will collaborate with various teams, including sales, marketing and other Business Development…

Expected salary:

Location: Swords, Co Dublin

Job date: Thu, 22 Aug 2024 03:26:18 GMT

Apply for the job now!

29Aug

Business Controller

Job title: Business Controller

Company: Eurofins

Job description: and ambitious Business Controller to join our team. This is not just another finance job; it’s a unique opportunity to dive… to Innovation: At Eurofins, we are dedicated to entrepreneurship and innovation. Our state-of-the-art laboratories and cutting-edge…

Expected salary:

Location: Dublin

Job date: Fri, 23 Aug 2024 01:55:40 GMT

Apply for the job now!

29Aug

Business Analyst, Digital

Job title: Business Analyst, Digital

Company: Primark

Job description: Job Description Digital Business Analyst Our Technology teams are right at the heart of what we do. Surrounded… by some of the best Technology specialists in the industry, you’ll bring your own ideas to the business – helping to shape the…

Expected salary:

Location: Dublin

Job date: Fri, 23 Aug 2024 04:45:04 GMT

Apply for the job now!

29Aug

Head of Investment Data Research at Vanguard – Malvern, PA


Head of Investment Data Research

Our mission starts with you!

Vanguard is one of the world’s largest and most respected investment management companies, known for its client-centric approach, low-cost investment products, and commitment to long-term, data-driven investment strategies. Our Investment Management Product Team is dedicated to developing innovative solutions that meet the evolving needs of our clients while leveraging the power of data to inform and optimize investment decisions. 

The Head of Investment Data Research will lead the data research function within the Investment Management Product Team, driving the strategy, development, and execution of data-driven research initiatives that enhance Vanguard’s investment products and strategies. This role will be responsible for overseeing the collection, analysis, and application of investment data to support product development, portfolio management, and strategic decision-making across Vanguard’s investment offerings. 

  

Key Responsibilities:

  •  Develop and execute a comprehensive data research strategy that aligns with Vanguard’s investment management goals, focusing on delivering actionable insights that drive product innovation and portfolio performance.
  • Oversee the identification, acquisition, and integration of diverse data sources, including market data, alternative data, and proprietary research, to support the development of investment products and strategies. 
  • Build, manage, and mentor a high-performing team of data scientists, quantitative researchers, and analysts, fostering a culture of innovation, collaboration, and continuous improvement. 

  • Work closely with product managers, portfolio managers, and other key stakeholders across Vanguard to ensure data research initiatives are aligned with business needs and investment objectives. 

  • Drive the exploration and adoption of new data technologies, tools, and methodologies to enhance Vanguard’s data research capabilities and competitive advantage in the investment management industry. 

  • Ensure the accuracy, reliability, and security of all investment data through robust data governance practices, including data validation, quality control, and compliance with industry regulations. 

  • Lead the development of advanced analytical models and data-driven insights that inform investment decisions, product development, and client engagement strategies. 

  • Serve as a thought leader within Vanguard and the broader investment community, representing the firm at industry conferences, publishing research findings, and contributing to thought leadership initiatives. 

  • Promote a culture of continuous improvement within the data research team, leveraging feedback, industry trends, and best practices to refine and enhance research methodologies. 

 Qualifications: 

  • Bachelor’s degree in Finance, Economics, Data Science, Computer Science, or a related field; Master’s degree or Ph.D. preferred. 

  • 10+ years of experience in investment data research, quantitative analysis, or a related field, with significant leadership experience in a financial services or investment management environment. 

  • Deep expertise in data science, quantitative research, and statistical modeling, with proficiency in tools such as Python, R, SQL, and advanced data visualization platforms. 

  • Extensive knowledge of investment management, including portfolio construction, asset allocation, risk management, and the application of data research to investment strategies. 

  • Excellent verbal and written communication skills, with the ability to present complex research findings to both technical and non-technical audiences, including senior leadership. 

  • In-depth understanding of the investment management industry, including current trends, challenges, and opportunities, with a focus on the evolving role of data in investment decision-making. 

Special Factors

Sponsorship

Vanguard is not offering visa sponsorship for this position.

About Vanguard

We are Vanguard. Together, we’re changing the way the world invests.

For us, investing doesn’t just end in value. It starts with values. Because when you invest with courage, when you invest with clarity, and when you invest with care, you can get so much more in return. We invest with purpose – and that’s how we’ve become a global market leader. Here, we grow by doing the right thing for the people we serve. And so can you.

We want to make success accessible to everyone. This is our opportunity. Let’s make it count.

Inclusion Statement

Vanguard’s continued commitment to diversity and inclusion is firmly rooted in our culture. Every decision we make to best serve our clients, crew (internally employees are referred to as crew), and communities is guided by one simple statement: “Do the right thing.”

We believe that a critical aspect of doing the right thing requires building diverse, inclusive, and highly effective teams of individuals who are as unique as the clients they serve. We empower our crew to contribute their distinct strengths to achieving Vanguard’s core purpose through our values.

When all crew members feel valued and included, our ability to collaborate and innovate is amplified, and we are united in delivering on Vanguard’s core purpose.

Our core purpose: To take a stand for all investors, to treat them fairly, and to give them the best chance for investment success.

How We Work

Vanguard has implemented a hybrid working model for the majority of our crew members, designed to capture the benefits of enhanced flexibility while enabling in-person learning, collaboration, and connection. We believe our mission-driven and highly collaborative culture is a critical enabler to support long-term client outcomes and enrich the employee experience.



Source link

29Aug

HR Business Partner

Job title: HR Business Partner

Company: Clark Recruitment

Job description: HR Business Partner HR Business Partner – Immediate Start (Contract Role) Location: Carlow, Hybrid Working… organization committed to driving innovation and excellence within the agricultural and food sectors. They are seeking a highly…

Expected salary:

Location: Carlow

Job date: Fri, 23 Aug 2024 22:02:43 GMT

Apply for the job now!

29Aug

Business Intelligence Consultant

Job title: Business Intelligence Consultant

Company: WiiGroup

Job description: standards. Join us as we shape the future of construction and create a world where innovation and efficiency thrive… forefront of the rapidly evolving AEC landscape. Innovation and pushing boundaries are paramount in the construction industry…

Expected salary:

Location: Limerick

Job date: Fri, 23 Aug 2024 22:41:03 GMT

Apply for the job now!

29Aug

Business Quality Assurance (English + Russian/Ukrainian)

Job title: Business Quality Assurance (English + Russian/Ukrainian)

Company: U Trust Insurance Agency LLC

Job description: . Join us to be a part of a company that values innovation, quality, and a customer-first approach in all aspects of our business…. Job Summary: The Business Quality Assurance Specialist at U Trust Insurance Agency LLC plays a crucial role in enhancing the…

Expected salary:

Location: Dublin

Job date: Fri, 23 Aug 2024 22:50:34 GMT

Apply for the job now!

Protected by Security by CleanTalk